Affinity Direct vs HumeCare+: Tirzepatide & Semaglutide Prices Compared (2026)
Updated 3 November 2026.
The Affinity Direct and HumeCare+ price guides were read that day and still show the recorded figures below.
Affinity Direct's Last verified line is 1 November 2026.
It lists compounded semaglutide at 1 mg a week for $152.15 every 4 weeks, with a $165.28 annualized monthly equivalent on a 365-day basis, and compounded tirzepatide at 2.5 mg a week for $147.90 every 4 weeks, with a $160.67 annualized monthly equivalent.
Both Affinity Direct rows were checked 27 October 2026.
A charge every 4 weeks is not a calendar-month price, and the annualized figure is not a second bill.
No oral semaglutide, NAD+, or peptide price is on the Affinity Direct price guide.
HumeCare+'s Last verified line is 2 November 2026.
It lists the physician-guided GLP-1Rx protocol for compounded semaglutide at $199/month, billed monthly.
That line says the FAQ starts at $199 for the first 4-week supply, then $199/mo, names compounded semaglutide, and says medication is included if prescribed, with extra charges possible.
It was checked 2 November 2026.
The compounded tirzepatide line says the page has a Compounded Tirzepatide button, the $199/month line names compounded semaglutide, and no separate tirzepatide dollar is printed.
The oral GLP line is an introductory offer from $7 a day, checked 2 November 2026.
It does not show $199 a month and does not name tirzepatide. $7 a day is not recorded as a monthly price.
A separate peptide line is an introductory offer from $199/mo, checked 2 November 2026.
It does not name one peptide ingredient.
Published Nov 3, 2026. Prices checked Nov 3, 2026.
GLP-1 prices on different billing bases
Figures are the lines on the Affinity Direct and HumeCare+ price guides, read 3 November 2026. Each cell keeps that row's recorded check date. A charge every 4 weeks, an annualized equivalent, and a price billed monthly are different bills.
| Charge | Affinity Direct | HumeCare+ |
|---|---|---|
| Compounded semaglutide compounded (not FDA-approved) | 1 mg a week. $152.15 every 4 weeks; $165.28 annualized monthly equivalent (365-day basis). The annualized figure is not a second bill. A 4-week charge is not a calendar-month price. Checked 27 October 2026. The price guide's Last verified line is 1 November 2026. | $199/month, billed monthly. The FAQ also says it starts at $199 for the first 4-week supply, then $199/mo, and names compounded semaglutide. Medication included if prescribed; extra charges possible. Checked 2 November 2026. compounded (not FDA-approved) |
| Compounded tirzepatide compounded (not FDA-approved) | 2.5 mg a week. $147.90 every 4 weeks; $160.67 annualized monthly equivalent (365-day basis). The annualized figure is not a second bill. A 4-week charge is not a calendar-month price. Checked 27 October 2026. | The price guide says the page has a Compounded Tirzepatide button. The $199/month line names compounded semaglutide. No separate tirzepatide dollar is printed. Checked 2 November 2026. compounded (not FDA-approved) |
| Other recorded plans | No oral semaglutide, NAD+, or peptide price is listed. | The oral line is an introductory offer from $7 a day. It does not show $199 a month and does not name tirzepatide. $7 a day is not recorded as a monthly price. A separate peptide line is an introductory offer from $199/mo and does not name one peptide ingredient. Both lines were checked 2 November 2026. |
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Affinity Direct
- Ranked offers
- 2
- Lowest ranked offer
- $160.67/mo
HumeCare+
- Ranked offers
- 0
- Lowest ranked offer
- No ranked offer
Published prices on record
Each figure is the provider’s recorded price, with the page it was read from and the date it was checked. A starting price is not the same billing basis as a continuing monthly price.
Affinity Direct
| Program | Price | Checked | Source |
|---|---|---|---|
| Compounded Semaglutide — 1 mg/weekCompounded semaglutide injection | $152.15 every 4 weeks; $165.28 annualized monthly equivalent (365-day basis) | 27 October 2026 | Source |
| Compounded Tirzepatide — 2.5 mg/weekCompounded tirzepatide injection | $147.90 every 4 weeks; $160.67 annualized monthly equivalent (365-day basis) | 27 October 2026 | Source |
HumeCare+
| Program | Price | Checked | Source |
|---|---|---|---|
| HumeCare Physician Guided GLP-1Rx Protocol (compounded semaglutide)Weekly subcutaneous injection; clinician-selected compounded formula | $199/month, billed monthly. The FAQ also says it starts at $199 for the first 4-week supply, then $199/mo, and names compounded semaglutide. Medication included if prescribed; extra charges possible. | 2 November 2026 | Source |
| HumeCare Physician Guided GLP-1Rx Protocol (compounded tirzepatide)Weekly subcutaneous injection; clinician-selected compounded formula | The page has a Compounded Tirzepatide button. The $199/month line names compounded semaglutide. No separate tirzepatide dollar is printed. | 2 November 2026 | Source |
| HumeCare Physician Guided Oral GLP ProtocolDaily oral GLP-1; exact compounded medication clinician-selected | Introductory offer from $7 a day. Automatic refills, cancel anytime. The page does not show $199 a month and does not name tirzepatide. $7 a day is not recorded as a monthly price. | 2 November 2026 | Source |
| Physician Guided Weight Loss Peptide ProtocolPhysician-guided weight-loss peptide protocol; medication clinician-selected | Introductory offer from $199/mo • automatic refills, cancel anytime | 2 November 2026 | Source |
Programs both providers publish
No directly comparable programme format is currently recorded for both providers.
Related pages
Common questions
- Do Affinity Direct and HumeCare+ use the same billing basis?
- No. Affinity Direct's price guide charges every 4 weeks. Those rows were checked 27 October 2026, and the guide's Last verified line is 1 November 2026. HumeCare+'s price guide, checked 2 November 2026, lists compounded semaglutide at $199/month, billed monthly. Four weekly doses are 28 days, not a calendar month.
- Is Affinity Direct's $152.15 a calendar-month price?
- No. It is the compounded semaglutide charge at 1 mg a week, $152.15 every 4 weeks, checked 27 October 2026. The same line prints $165.28 as the annualized monthly equivalent on a 365-day basis. Compounded tirzepatide at 2.5 mg a week is $147.90 every 4 weeks, with a $160.67 annualized equivalent. The annualized figure is not a second bill.
- Does HumeCare+ publish a separate compounded tirzepatide price?
- No separate tirzepatide dollar is printed. The price guide, checked 2 November 2026, says the page has a Compounded Tirzepatide button and that the $199/month line names compounded semaglutide. The oral line is an introductory offer from $7 a day and does not name tirzepatide. $7 a day is not recorded as a monthly price.
- Does this page pick a GLP-1 for the reader?
- No. It compares published telehealth charges for compounded semaglutide and compounded tirzepatide. It does not choose a medicine or predict a personal result.
Sources and limits
Prices and terms can change. Confirm the current programme, eligibility, and total cost with the provider.
- Affinity Direct GLP-1 price page and CC BY price file Checked 21 October 2026. Fetched 21 October 2026. The page says prices as of 17 October 2026. A month is 4 weekly doses (28 days). Compounded tirzepatide at 2.5 mg/week is $174 one-time for 4 weeks, $147.90 auto-refill every 4 weeks, and $360.40 every 12 weeks on auto-refill ($120.14 per 28-day month). Compounded semaglutide at 1 mg/week is $179 one-time, $152.15 every 4 weeks, and $339.15 every 12 weeks ($113.05 per 28-day month). The 0.25 → 0.5 → 1 mg starter pack is $288.15 for 12 weeks on auto-refill and then continues at 1 mg for $339.15 every 12 weeks. Each price includes medication, provider review, syringes, alcohol prep pads, and cold shipping, with no membership, consultation, or shipping fee. Charged at checkout; full refund if not approved. Ships to all 50 states. The same figures are in https://affinitydirect.com/pricing/glp1-prices.json and the CSV, last updated 2026-10-17, CC BY 4.0. Compounded semaglutide and tirzepatide are not FDA-approved.
- Affinity Direct compounded semaglutide page Checked 21 October 2026. Fetched 21 October 2026. Prices as of 17 October 2026. The 1 mg/week row is $179 for a one-time 4-week supply and $152.15 auto-refill every 4 weeks. The 3-month auto-refill at 1 mg is $339.15 every 12 weeks ($113.05 a month). The standard starter pack, 0.25 → 0.5 → 1 mg weekly, is $288.15 with auto-refill ($96.05 a month) or $339 one time; auto-refill after that pack continues at 1 mg/week for $339.15 every 12 weeks. The page says there is no membership, consultation, or shipping fee, and that a declined intake is refunded in full. It says compounded semaglutide is not FDA-approved and that treatment is offered in all 50 states.
- Affinity Direct compounded tirzepatide page Checked 21 October 2026. Fetched 21 October 2026. Prices as of 17 October 2026. The 2.5 mg/week row is $174 for a one-time 4-week supply and $147.90 auto-refill every 4 weeks. The 3-month auto-refill at 2.5 mg is $360.40 every 12 weeks ($120.14 a month). The 4-week auto-refill ladder runs from $147.90 at 2.5 mg to $228.65 at 15 mg. The 2.5 → 5 → 7.5 mg starter pack is a separate protocol. The page says there is no membership, consultation, or shipping fee, and that a declined intake is refunded in full. It says compounded tirzepatide is not FDA-approved and that treatment is offered in all 50 states.
- HumeCare GLP-1Rx page, 2 November 2026 Checked 2 November 2026. Rechecked 2 November 2026. The page still says $199/month, billed monthly, and the FAQ still says it starts at $199 for the first 4-week supply, then $199/mo, and names compounded semaglutide. The FAQ's unavailable list names Alabama, Louisiana, and Mississippi and does not name Arkansas. No separate tirzepatide dollar is printed.
- HumeCare oral GLP page, 2 November 2026 Checked 2 November 2026. Rechecked 2 November 2026. The visible offer is still an introductory offer from $7 a day, with automatic refills and cancel anytime. The page does not show $199 a month and does not name tirzepatide.
- HumeCare peptide page, 2 November 2026 Checked 2 November 2026. Rechecked 2 November 2026. The page still shows an introductory offer from $199 a month, with automatic refills and cancel anytime. It does not name one peptide ingredient.